Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

The Murine Double Minute 2 (MDM2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. Similarly, the PI3-Kinase (PI3K)/AKT pathway is critical for growth factor-mediated cell survival. Additionally, it has been reported that AKT...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Du, Wei, Yi, Yong, Zhang, Haibo, Bergholz, Johann, Wu, Junfeng, Ying, Haoqiang, Zhang, Yujun, Xiao, Zhi-Xiong Jim
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640086/
https://ncbi.nlm.nih.gov/pubmed/23638184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063179
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares