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FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2
The FK506-binding protein 12 (FKBP12) is a cytoplasmic protein and has been reported to possess multiple functions in signaling transduction based on its interaction with different cellular targets. Here, we report that FKBP12 interacts with oncoprotein MDM2 and induces MDM2 degradation. We demonstr...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378873/ https://ncbi.nlm.nih.gov/pubmed/27617579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.331 |
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