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Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection

Cortical thymic epithelial cells (cTECs) express a unique thymoproteasome subunit-β5T that plays an essential role in the development of CD8 T cells. In contrast, the immunoproteasome subunit-β5i is expressed in other thymic antigen-presenting cells (APCs). The thymoproteasome may generate peptides...

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書目詳細資料
Main Authors: Xing, Yan, Jameson, Stephen C., Hogquist, Kristin A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637736/
https://ncbi.nlm.nih.gov/pubmed/23569244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222244110
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