Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells

Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II. Instead, cortical thymocytes express non-peptide presenting MHC molecules like CD1d and MR1, and promote the selection...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Georgiev, Hristo, Peng, Changwei, Huggins, Matthew A., Jameson, Stephen C., Hogquist, Kristin A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052364/
https://ncbi.nlm.nih.gov/pubmed/33863906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22589-z
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