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The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens

The strength of self-peptide–major histocompatibility complex (MHC) recognition dictates naïve CD8(+) T cell homeostasis, but its effect on foreign antigen reactivity is controversial. As CD5 expression correlates with self-recognition, we studied CD5(lo) and CD5(hi) naïve CD8(+) T cells. Gene expre...

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Vydáno v:	Nat Immunol
Hlavní autoři:	Fulton, Ross B., Hamilton, Sara E., Xing, Yan, Best, J. Adam, Goldrath, Ananda W., Hogquist, Kristin A., Jameson, Stephen C.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2014
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4270846/ https://ncbi.nlm.nih.gov/pubmed/25419629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3043
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The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens

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