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The self-obsession of T cells: how TCR signaling thresholds affect fate decisions in the thymus and effector function in the periphery

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. We now appreciate that the T cell repertoire is in fact, broadly self-reactive, one could even say self-centered. The strength with which a T...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Immunol
Egile Nagusiak: Hogquist, Kristin A., Jameson, Stephen C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348363/
https://ncbi.nlm.nih.gov/pubmed/25137456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2938
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