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The self-obsession of T cells: how TCR signaling thresholds affect fate decisions in the thymus and effector function in the periphery
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. We now appreciate that the T cell repertoire is in fact, broadly self-reactive, one could even say self-centered. The strength with which a T...
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| Wydane w: | Nat Immunol |
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| Główni autorzy: | , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348363/ https://ncbi.nlm.nih.gov/pubmed/25137456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2938 |
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