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Coevolution of TCR-MHC interactions: Conserved MHC tertiary structure is not sufficient for interactions with the TCR

The specificity for self-MHC that is necessary for T cell function is a consequence of intrathymic selection during which T cell antigen receptors (TCRs) expressed by immature thymocytes are tested for their affinity for self-peptide:self-MHC. The germ-line-encoded segments of the TCR, however, are...

詳細記述

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書誌詳細
主要な著者: Kim, Hye-Jung, Guo, Donglin, Sant'Angelo, Derek B.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091755/
https://ncbi.nlm.nih.gov/pubmed/15883386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502751102
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