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Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic exclusion has been shown to be leaky for the β chain and, more commonly, for the α chain. Here, we d...

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Detalhes bibliográficos
Main Authors: Sant'Angelo, Derek B., Cresswell, Peter, Janeway, Charles A., Denzin, Lisa K.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC34437/
https://ncbi.nlm.nih.gov/pubmed/11381132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121179998
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