Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic exclusion has been shown to be leaky for the β chain and, more commonly, for the α chain. Here, we d...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Sant'Angelo, Derek B., Cresswell, Peter, Janeway, Charles A., Denzin, Lisa K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11381132/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121179998
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