Epithelial Cell TGFβ Signaling Induces Acute Tubular Injury and Interstitial Inflammation

TGFβ signaling plays a central role in the development of acute and chronic kidney diseases. Previous in vivo studies involved systemic alteration of TGFβ signaling, however, limiting conclusions about the direct role of TGFβ in tubular cell injury. Here, we generated a double transgenic mouse that...

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Autori principali: Gentle, Madeleine E., Shi, Shaolin, Daehn, Ilse, Zhang, Taoran, Qi, Haiying, Yu, Liping, D’Agati, Vivette D., Schlondorff, Detlef O., Bottinger, Erwin P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2013
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636798/
https://ncbi.nlm.nih.gov/pubmed/23539761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012101024
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