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Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice
BACKGROUND & AIMS: Phosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase Akt and mammalian target of rapamycin complex (mTORC1) are effectors of PI3K that promote cell growth and survival, but their individual roles in tu...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633657/ https://ncbi.nlm.nih.gov/pubmed/23376645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.01.053 |
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