Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice

BACKGROUND & AIMS: Phosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase Akt and mammalian target of rapamycin complex (mTORC1) are effectors of PI3K that promote cell growth and survival, but their individual roles in tu...

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Main Authors: Kenerson, Heidi L., Yeh, Matthew M., Kazami, Machiko, Jiang, Xiuyun, Riehle, Kimberly J., McIntyre, Rebecca L., Park, James O., Kwon, Steve, Campbell, Jean S., Yeung, Raymond S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633657/
https://ncbi.nlm.nih.gov/pubmed/23376645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.01.053
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