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Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt

Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protec...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Kenerson, Heidi L., Subramanian, Savitha, McIntyre, Rebecca, Kazami, Machiko, Yeung, Raymond S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315590/
https://ncbi.nlm.nih.gov/pubmed/25646773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117000
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