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Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt
Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis in mouse livers, but instead, protec...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4315590/ https://ncbi.nlm.nih.gov/pubmed/25646773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117000 |
| Oznake: |
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