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mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve its scaffolding mTOR kinase with substrate. Here we...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4729872/ https://ncbi.nlm.nih.gov/pubmed/26743335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10255 |
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