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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Increased hepatic lipid content is an early correlate of insulin resistance, and can be caused by nutrient-induced mTor activation. The latter increases basal Akt activity, leading to a self-perpetuating lipogenic cycle. We have previously shown that the developmental Notch pathway has metabolic fun...

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Autori principali: Pajvani, Utpal B., Qiang, Li, Kangsamaksin, Thaned, Kitajewski, Jan, Ginsberg, Henry N., Accili, Domenico
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737382/
https://ncbi.nlm.nih.gov/pubmed/23832089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3259
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