mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Gastrointestinal cancers are frequently associated with chronic inflammation and excessive secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation of the GP130/JAK/STAT3 pathway. Although tumor progression can be prevented by genetic ablation of Stat3 in mice, t...

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Main Authors: Thiem, Stefan, Pierce, Thomas P., Palmieri, Michelle, Putoczki, Tracy L., Buchert, Michael, Preaudet, Adele, Farid, Ryan O., Love, Chris, Catimel, Bruno, Lei, Zhengdeng, Rozen, Steve, Gopalakrishnan, Veena, Schaper, Fred, Hallek, Michael, Boussioutas, Alex, Tan, Patrick, Jarnicki, Andrew, Ernst, Matthias
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561832/
https://ncbi.nlm.nih.gov/pubmed/23321674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65086
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