mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

Gastrointestinal cancers are frequently associated with chronic inflammation and excessive secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation of the GP130/JAK/STAT3 pathway. Although tumor progression can be prevented by genetic ablation of Stat3 in mice, t...

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Hlavní autoři: Thiem, Stefan, Pierce, Thomas P., Palmieri, Michelle, Putoczki, Tracy L., Buchert, Michael, Preaudet, Adele, Farid, Ryan O., Love, Chris, Catimel, Bruno, Lei, Zhengdeng, Rozen, Steve, Gopalakrishnan, Veena, Schaper, Fred, Hallek, Michael, Boussioutas, Alex, Tan, Patrick, Jarnicki, Andrew, Ernst, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561832/
https://ncbi.nlm.nih.gov/pubmed/23321674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65086
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