Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis

The mechanistic target of rapamycin complex 2 (mTORC2) is a potentially novel and promising anticancer target due to its critical roles in proliferation, apoptosis, and metabolic reprogramming of cancer cells. However, the activity and function of mTORC2 in distinct cells within malignant tissue in...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Katholnig, Karl, Schütz, Birgit, Fritsch, Stephanie D., Schörghofer, David, Linke, Monika, Sukhbaatar, Nyamdelger, Matschinger, Julia M., Unterleuthner, Daniela, Hirtl, Martin, Lang, Michaela, Herac, Merima, Spittler, Andreas, Bergthaler, Andreas, Schabbauer, Gernot, Bergmann, Michael, Dolznig, Helmut, Hengstschläger, Markus, Magnuson, Mark A., Mikula, Mario, Weichhart, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824305/
https://ncbi.nlm.nih.gov/pubmed/31619583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124164
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