Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the loss-of-function of fragile X mental retardation protein (FMRP). The loss of FMRP function in neurons abolishes its suppression on mGluR1/5-dependent dendritic protein translation, enhancing mGluR1/5-dependent synaptic plasticit...

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Hlavní autoři: Higashimori, Haruki, Morel, Lydie, Huth, James, Lindemann, Lothar, Dulla, Chris, Taylor, Amaro, Freeman, Mike, Yang, Yongjie
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633372/
https://ncbi.nlm.nih.gov/pubmed/23396537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt055
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