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Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling

The loss of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the most common inherited intellectual disability. How the loss of FMRP alters protein expression and astroglial functions remains essentially unknown. Here we showed that selective loss of astroglial FMRP in vi...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Men, Yuqin, Ye, Liang, Risgaard, Ryan D., Promes, Vanessa, Zhao, Xinyu, Paukert, Martin, Yang, Yongjie
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547241/
https://ncbi.nlm.nih.gov/pubmed/32958647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014080117
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