‘Ryanopathy’: causes and manifestations of RyR2 dysfunction in heart failure

The cardiac ryanodine receptor (RyR2), a Ca(2+) release channel on the membrane of the sarcoplasmic reticulum (SR), plays a key role in determining the strength of the heartbeat by supplying Ca(2+) required for contractile activation. Abnormal RyR2 function is recognized as an important part of the...

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Bibliografiske detaljer
Main Authors: Belevych, Andriy E., Radwański, Przemysław B., Carnes, Cynthia A., Györke, Sandor
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Spotlight Reviews: Spotlight on T-Tubules and Ryanodine Receptor Microdomain Signalling in Cardiac Hypertrophy and Failure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633158/
https://ncbi.nlm.nih.gov/pubmed/23408344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt024
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