Persistence of Resistant Variants in Hepatitis C Virus-Infected Patients Treated with the NS5A Replication Complex Inhibitor Daclatasvir

Daclatasvir (DCV; BMS-790052) is a hepatitis C virus (HCV) NS5A replication complex inhibitor (RCI) with picomolar to low nanomolar potency and broad genotypic coverage in vitro. Viral RNA declines have been observed in the clinic for both alpha interferon-ribavirin (IFN-α–RBV) and IFN-RBV-free regi...

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Hlavní autoři: Wang, Chunfu, Sun, Jin-Hua, O'Boyle, Donald R., Nower, Peter, Valera, Lourdes, Roberts, Susan, Fridell, Robert A., Gao, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632915/
https://ncbi.nlm.nih.gov/pubmed/23403428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02494-12
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