In Vitro Activity of Daclatasvir on Hepatitis C Virus Genotype 3 NS5A

The NS5A replication complex inhibitor daclatasvir (DCV; BMS-790052) inhibits hybrid replicons containing hepatitis C virus (HCV) genotype 3a (HCV3a) NS5A genes with 50% effective concentrations (EC(50)s) ranging from 120 to 870 pM. Selection studies with a hybrid HCV3a replicon identified NS5A resi...

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Main Authors: Wang, Chunfu, Valera, Lourdes, Jia, Lingling, Kirk, Melissa J., Gao, Min, Fridell, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535966/
https://ncbi.nlm.nih.gov/pubmed/23089758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01874-12
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