Persistence of Resistant Variants in Hepatitis C Virus-Infected Patients Treated with the NS5A Replication Complex Inhibitor Daclatasvir

Daclatasvir (DCV; BMS-790052) is a hepatitis C virus (HCV) NS5A replication complex inhibitor (RCI) with picomolar to low nanomolar potency and broad genotypic coverage in vitro. Viral RNA declines have been observed in the clinic for both alpha interferon-ribavirin (IFN-α–RBV) and IFN-RBV-free regi...

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Autori principali: Wang, Chunfu, Sun, Jin-Hua, O'Boyle, Donald R., Nower, Peter, Valera, Lourdes, Roberts, Susan, Fridell, Robert A., Gao, Min
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632915/
https://ncbi.nlm.nih.gov/pubmed/23403428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02494-12
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