FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and specificity to one of the receptor and coreceptor pairs...

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Detalhes bibliográficos
Main Authors: Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R., Alba, Benjamin M., Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W., Véniant, Murielle M., Li, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632592/
https://ncbi.nlm.nih.gov/pubmed/23630589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061432
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