Characterization of a FGF19 Variant with Altered Receptor Specificity Revealed a Central Role for FGFR1c in the Regulation of Glucose Metabolism

Diabetes and associated metabolic conditions have reached pandemic proportions worldwide, and there is a clear unmet medical need for new therapies that are both effective and safe. FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Both have potent effect...

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Hlavní autoři: Ge, Hongfei, Baribault, Helene, Vonderfecht, Steven, Lemon, Bryan, Weiszmann, Jennifer, Gardner, Jonitha, Lee, Ki Jeong, Gupte, Jamila, Mookherjee, Paramita, Wang, Minghan, Sheng, Jackie, Wu, Xinle, Li, Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311646/
https://ncbi.nlm.nih.gov/pubmed/22457778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033603
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