FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and specificity to one of the receptor and coreceptor pairs...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R., Alba, Benjamin M., Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W., Véniant, Murielle M., Li, Yang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632592/
https://ncbi.nlm.nih.gov/pubmed/23630589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061432
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