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Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics
The 2-azetidinone ring of the Class A and D β-lactamase inhibitor clavulanic acid (1) is synthesized by the ATP-utilizing enzyme β-lactam synthetase (βLS). A hydroxyethyl group attached to C-6 of 1 in the (S) configuration markedly enhances the efficacy of this compound against Class C β-lactamases....
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632419/ https://ncbi.nlm.nih.gov/pubmed/23616913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD00305H |
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