RiPPing apart the rules for peptide natural products

av Imani, Aman S., Freeman, Michael F.
I publikationen Synth Syst Biotechnol (2018)

Dissection of the Stepwise Mechanism to β-Lactam Formation and Elucidation of a Rate-determining Conformational Change in β-Lactam Synthetase

av Raber, Mary L., Freeman, Michael F., Townsend, Craig A.
Publicerad 2009

Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT

av Buller, Andrew R., Freeman, Michael F., Schildbach, Joel F., Townsend, Craig A.
Publicerad 2014

Genome mining- and synthetic biology-enabled production of hypermodified peptides

av Bhushan, Agneya, Egli, Peter J., Peters, Eike E., Freeman, Michael F., Piel, Jörn
I publikationen Nat Chem (2019)

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

av Freeman, Michael F., Moshos, Kristos A., Bodner, Micah J., Li, Rongfeng, Townsend, Craig A.
Publicerad 2008

Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

av Bodner, Micah J., Phelan, Ryan M., Freeman, Michael F., Li, Rongfeng, Townsend, Craig A.
Publicerad 2010

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

av Buller, Andrew R., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Publicerad 2012

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics

av Labonte, Jason W., Kudo, Fumitaka, Freeman, Michael F., Raber, Mary L., Townsend, Craig A.
Publicerad 2012

Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis

av Buller, Andrew R., Labonte, Jason W., Freeman, Michael F., Wright, Nathan T., Schildbach, Joel F., Townsend, Craig A.
Publicerad 2012

Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis

av Bodner, Micah J., Li, Rongfeng, Phelan, Ryan M., Freeman, Michael F., Moshos, Kristos A., Lloyd, Evan P., Townsend, Craig A.
Publicerad 2011

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

av Rust, Michael, Helfrich, Eric J. N., Freeman, Michael F., Nanudorn, Pakjira, Field, Christopher M., Rückert, Christian, Kündig, Tomas, Page, Michael J., Webb, Victoria L., Kalinowski, Jörn, Sunagawa, Shinichi, Piel, Jörn
I publikationen Proc Natl Acad Sci U S A (2020)

A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

av Song, Haigang, van der Velden, Niels S., Shiran, Sally L., Bleiziffer, Patrick, Zach, Christina, Sieber, Ramon, Imani, Aman S., Krausbeck, Florian, Aebi, Markus, Freeman, Michael F., Riniker, Sereina, Künzler, Markus, Naismith, James H.
I publikationen Sci Adv (2018)