A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl. While chemical methylat...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Song, Haigang, van der Velden, Niels S., Shiran, Sally L., Bleiziffer, Patrick, Zach, Christina, Sieber, Ramon, Imani, Aman S., Krausbeck, Florian, Aebi, Markus, Freeman, Michael F., Riniker, Sereina, Künzler, Markus, Naismith, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108569/
https://ncbi.nlm.nih.gov/pubmed/30151425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat2720
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