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Dissection of the Stepwise Mechanism to β-Lactam Formation and Elucidation of a Rate-determining Conformational Change in β-Lactam Synthetase
Clavulanic acid is a widely used β-lactamase inhibitor whose key β-lactam core is formed by β-lactam synthetase. β-Lactam synthetase exhibits a Bi-Ter mechanism consisting of two chemical steps, acyl-adenylation followed by β-lactam formation. (32)PP(i)-ATP exchange assays showed the first irreversi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610506/ https://ncbi.nlm.nih.gov/pubmed/18955494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805390200 |
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