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A Conserved Tyrosyl–Glutamyl Catalytic Dyad in Evolutionarily Linked Enzymes: Carbapenam Synthetase and β-Lactam Synthetase
β-Lactam-synthesizing enzymes carbapenam synthetase (CPS) and β-lactam synthetase (β-LS) are evolutionarily linked to a common ancestor, asparagine synthetase B (AS-B). These three relatives catalyze substrate acyl-adenylation and nucleophilic acyl substitution by either an external (AS-B) or intern...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2833280/ https://ncbi.nlm.nih.gov/pubmed/19371088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900432n |
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