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β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis
Non-ribosomal peptide synthetases (NRPSs) are giant enzymes comprised of modules that house repeated sets of functional domains, which select, activate and couple amino acids drawn from a pool of nearly 500 potential building blocks.(1) The structurally and stereochemically diverse peptides generate...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4401618/ https://ncbi.nlm.nih.gov/pubmed/25624104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14100 |
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