Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins

BACKGROUND AND PURPOSE: Adult rat dorsal root ganglion (DRG) neurons normally express transcripts for five isoforms of the α-subunit of voltage-gated sodium channels: Na(V)1.1, 1.6, 1.7, 1.8 and 1.9. Tetrodotoxin (TTX) readily blocks all but Na(V)1.8 and 1.9, and pharmacological agents that discrimi...

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Bibliographic Details
Main Authors: Zhang, Min-Min, Wilson, Michael J, Gajewiak, Joanna, Rivier, Jean E, Bulaj, Grzegorz, Olivera, Baldomero M, Yoshikami, Doju
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632242/
https://ncbi.nlm.nih.gov/pubmed/23351163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12119
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