The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an important role in controlling mammalian blood pressure by modulating the activity of ion co-transporters in the kidney. Recent studies have identifi...

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Main Authors: Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J., Wood, Nicola T., Alessi, Dario R., Kurz, Thimo
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2013
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Accelerated Publication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632089/
https://ncbi.nlm.nih.gov/pubmed/23387299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121903
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