The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A

The cullin-RING family of ubiquitin ligases regulates diverse cellular functions, such as cell cycle control, via ubiquitylation of specific substrates. CUL3 targets its substrates through BTB proteins. Here we show that depletion of CUL3 and the BTB protein KLHL18 causes a delay in mitotic entry. C...

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Hlavní autoři: Moghe, Saili, Jiang, Fei, Miura, Yoshie, Cerny, Ronald L., Tsai, Ming-Ying, Furukawa, Manabu
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507203/
https://ncbi.nlm.nih.gov/pubmed/23213400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.2011018
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