Relative stabilities of IgG1 and IgG4 Fab domains: Influence of the light–heavy interchain disulfide bond architecture

The stability of therapeutic antibodies is a prime pharmaceutical concern. In this work we examined thermal stability differences between human IgG1 and IgG4 Fab domains containing the same variable regions using the thermofluor assay. It was found that the IgG1 Fab domain is up to 11°C more stable...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Heads, James T, Adams, Ralph, D'Hooghe, Lena E, Page, Matt J T, Humphreys, David P, Popplewell, Andrew G, Lawson, Alastair D, Henry, Alistair J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wiley Subscription Services, Inc., A Wiley Company 2012
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631360/
https://ncbi.nlm.nih.gov/pubmed/22761163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2118
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg