Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange

Interdomain interactions between the CH3 domains of antibody heavy chains are the first step in antibody assembly and are of prime importance for maintaining the native structure of IgG. For human IgG4 it was shown that CH3-CH3 interactions are weak, resulting in the potential for half-molecule exch...

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Detalhes bibliográficos
Main Authors: Rispens, Theo, Davies, Anna M., Ooijevaar-de Heer, Pleuni, Absalah, Samira, Bende, Onno, Sutton, Brian J., Vidarsson, Gestur, Aalberse, Rob C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937676/
https://ncbi.nlm.nih.gov/pubmed/24425871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541813
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