Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

[Image: see text] We synthesized 30 lipophilic bisphosphonates and tested them in malaria parasite killing (targeting parasite geranylgeranyl diphosphate synthase, GGPPS) and human γδ T cell activation (targeting human farnesyl diphosphate synthase, FPPS). Similar patterns of activity were seen in i...

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Autors principals: Zhang, Yonghui, Zhu, Wei, Liu, Yi-Liang, Wang, Hong, Wang, Ke, Li, Kai, No, Joo Hwan, Ayong, Lawrence, Gulati, Anmol, Pang, Ran, Freitas-Junior, Lucio, Morita, Craig T., Oldfield, Eric
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630516/
https://ncbi.nlm.nih.gov/pubmed/23610597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000436
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