MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynt...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Edwards, Rachel L., Brothers, Robert C., Wang, Xu, Maron, Maxim I., Ziniel, Peter D., Tsang, Patricia S., Kraft, Thomas E., Hruz, Paul W., Williamson, Kim C., Dowd, Cynthia S., John, Audrey R. Odom
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567135/
https://ncbi.nlm.nih.gov/pubmed/28827774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07159-y
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