MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis

The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynt...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Edwards, Rachel L., Brothers, Robert C., Wang, Xu, Maron, Maxim I., Ziniel, Peter D., Tsang, Patricia S., Kraft, Thomas E., Hruz, Paul W., Williamson, Kim C., Dowd, Cynthia S., John, Audrey R. Odom
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567135/
https://ncbi.nlm.nih.gov/pubmed/28827774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07159-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items