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MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynt...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567135/ https://ncbi.nlm.nih.gov/pubmed/28827774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07159-y |
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