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Prodrugs of bisthiazolium salts are orally potent antimalarials
We created neutral antimalarial prodrugs that deliver bisthiazolium compounds with antimalarial activity in the nanomolar range. These drugs primarily affect early intraerythrocytic stages through rapid, nonreversible cytotoxicity. The compounds are suitable for both parenteral and oral use and plas...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523447/ https://ncbi.nlm.nih.gov/pubmed/15492221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404037101 |
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