Pharmacological Properties of a New Antimalarial Bisthiazolium Salt, T3, and a Corresponding Prodrug, TE3

A new approach to malarial chemotherapy based on quaternary ammonium that targets membrane biogenesis during intraerythrocytic Plasmodium falciparum development has recently been developed. To increase the bioavailability, nonionic chemically modified prodrugs were synthesized. In this paper, the ph...

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Bibliographic Details
Main Authors: Nicolas, Olivier, Margout, Delphine, Taudon, Nicolas, Wein, Sharon, Calas, Michèle, Vial, Henri J., Bressolle, Françoise M. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195427/
https://ncbi.nlm.nih.gov/pubmed/16127032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3631-3639.2005
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