Potent Antihematozoan Activity of Novel Bisthiazolium Drug T16: Evidence for Inhibition of Phosphatidylcholine Metabolism in Erythrocytes Infected with Babesia and Plasmodium spp.

A leading bisthiazolium drug, T16, designed to mimic choline, was shown to exert potent antibabesial activity, with 50% inhibitory concentrations of 28 and 7 nM against Babesia divergens and B. canis, respectively. T16 accumulated inside Babesia-infected erythrocytes (cellular accumulation ratio, &g...

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Hauptverfasser: Richier, Eric, Biagini, Giancarlo A., Wein, Sharon, Boudou, Frederic, Bray, Patrick G., Ward, Steve A., Precigout, Eric, Calas, Michèle, Dubremetz, Jean-François, Vial, Henri J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1610066/
https://ncbi.nlm.nih.gov/pubmed/17005821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00443-06
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