High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death

Albitiazolium is the lead compound of bisthiazolium choline analogues and exerts powerful in vitro and in vivo antimalarial activities. Here we provide new insight into the fate of albitiazolium in vivo in mice and how it exerts its pharmacological activity. We show that the drug exhibits rapid and...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Wein, Sharon, Taudon, Nicolas, Maynadier, Marjorie, Tran Van Ba, Christophe, Margout, Delphine, Bordat, Yann, Fraisse, Laurent, Wengelnik, Kai, Cerdan, Rachel, Bressolle-Gomeni, Françoise, Vial, Henri J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527631/
https://ncbi.nlm.nih.gov/pubmed/28607017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00352-17
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