High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death

Albitiazolium is the lead compound of bisthiazolium choline analogues and exerts powerful in vitro and in vivo antimalarial activities. Here we provide new insight into the fate of albitiazolium in vivo in mice and how it exerts its pharmacological activity. We show that the drug exhibits rapid and...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wein, Sharon, Taudon, Nicolas, Maynadier, Marjorie, Tran Van Ba, Christophe, Margout, Delphine, Bordat, Yann, Fraisse, Laurent, Wengelnik, Kai, Cerdan, Rachel, Bressolle-Gomeni, Françoise, Vial, Henri J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527631/
https://ncbi.nlm.nih.gov/pubmed/28607017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00352-17
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