New Insight into the Mechanism of Accumulation and Intraerythrocytic Compartmentation of Albitiazolium, a New Type of Antimalarial

Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis. They specifically accumulate in Plasmodium- and Babesia-infected red blood cells (IRBC). Here, we provide new insight into the choline analogue albitiazolium, which is currentl...

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Detalhes bibliográficos
Main Authors: Wein, Sharon, Tran Van Ba, Christophe, Maynadier, Marjorie, Bordat, Yann, Perez, Julie, Peyrottes, Suzanne, Fraisse, Laurent, Vial, Henri J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135818/
https://ncbi.nlm.nih.gov/pubmed/25001307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00040-14
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