High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death

Albitiazolium is the lead compound of bisthiazolium choline analogues and exerts powerful in vitro and in vivo antimalarial activities. Here we provide new insight into the fate of albitiazolium in vivo in mice and how it exerts its pharmacological activity. We show that the drug exhibits rapid and...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Wein, Sharon, Taudon, Nicolas, Maynadier, Marjorie, Tran Van Ba, Christophe, Margout, Delphine, Bordat, Yann, Fraisse, Laurent, Wengelnik, Kai, Cerdan, Rachel, Bressolle-Gomeni, Françoise, Vial, Henri J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527631/
https://ncbi.nlm.nih.gov/pubmed/28607017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00352-17
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