Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of the Hsp90 inhibitor PU-H71 that are capable of permeating cell membranes so as to enable the investigation of Hsp90 complexes in live cells....

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Main Authors: Taldone, Tony, Rodina, Anna, DaGama Gomes, Erica M, Riolo, Matthew, Patel, Hardik J, Alonso-Sabadell, Raul, Zatorska, Danuta, Patel, Maulik R, Kishinevsky, Sarah, Chiosis, Gabriela
Formáid: Artigo
Teanga:Inglês
Foilsithe: Beilstein-Institut 2013
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Full Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628991/
https://ncbi.nlm.nih.gov/pubmed/23616796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.60
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