Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

The mammalian target of rapamycin (mTOR) assembles into two distinct multi-protein complexes called mTORC1 and mTORC2. Whereas mTORC1 is known to regulate cell and organismal growth, the role of mTORC2 is less understood. We describe two mouse lines that are devoid of the mTORC2 component rictor in...

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Bibliografiske detaljer
Main Authors: Thomanetz, Venus, Angliker, Nico, Cloëtta, Dimitri, Lustenberger, Regula M., Schweighauser, Manuel, Oliveri, Filippo, Suzuki, Noboru, Rüegg, Markus A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628512/
https://ncbi.nlm.nih.gov/pubmed/23569215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205030
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