The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell cycle progression in malignant bladder cancer cells in vitro and in vivo

PURPOSE: Despite over 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluated Aurora kinase A, identified as an upregulated candidate molecule in bladder cancer, as a potential therapeuti...

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Detalhes bibliográficos
Main Authors: Zhou, Ning, Singh, Kamini, Mir, Maria C., Parker, Yvonne, Lindner, Daniel, Dreicer, Robert, Ecsedy, Jeffrey A, Zhang, Zhongfa, Teh, Bin T., Almasan, Alexandru, Hansel, Donna E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626291/
https://ncbi.nlm.nih.gov/pubmed/23403633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2383
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