Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket

Blockade of the angiotensin (ANG) II receptor type 1 (AT(1)R) with angiotensin receptor blockers (ARBs) is widely used in the treatment of hypertension. However, ARBs are variably effective in reducing blood pressure, likely due, in part, to polymorphisms in the ARB binding pocket of the AT(1)R. The...

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Hauptverfasser: Nistala, Ravi, Andresen, Bradley T., Pulakat, Lakshmi, Meuth, Alex, Sinak, Catherine, Mandavia, Chirag, Thekkumkara, Thomas, Speth, Robert C., Whaley-Connell, Adam, Sowers, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625841/
https://ncbi.nlm.nih.gov/pubmed/23389452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00127.2012
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